Clinicians report real-world results on the use of a new device to treat
brain aneurysms

Date:
January 6, 2022
Source:
Massachusetts General Hospital
Summary:
In an international study of patients with brain aneurysms
(balloon-like bulges in weakened blood vessels), the Woven
Endobridge device had a favorable efficacy and safety profile.



FULL STORY ==========================================================================
A recent international study led by researchers at Massachusetts General Hospital (MGH) and other institutions offers real-world results on the use
of a novel device for treating brain aneurysms, or balloon-like bulges
on weakened blood vessels that can rupture to cause life-threatening
bleeding.


==========================================================================
The study, which is published in Stroke, involved the use of the Woven Endobridge (WEB) device. This device consists of a tiny mesh plug that
can be inserted through a vessel and placed into an aneurysm to block, or occlude, blood from going into the bulging region -- thereby stabilizing
the vessel and preventing the aneurysm from rupturing. The device can
also be used to stabilize previously ruptured aneurysms.

"The WEB has recently become available in the United States, and elsewhere across the globe the device has been available for a longer time -- but
no large-scale study of its efficacy had yet been performed," says lead
author Adam A. Dmytriw, MD, MPH, MSc, an interventional neuroradiology
and endovascular neurosurgery fellow at MGH. "Thus, we founded the
WorldWideWEB Consortium uniting the experience of 22 tertiary/quaternary institutions across North America, Europe, South America, and Australia."
The team found that among 671 patients with 683 brain aneurysms (26.2% previously ruptured) who were treated with the device and were followed
for a median of 11 months, adequate occlusion occurred in 85.7% of
aneurysms, and complete occlusion in 57.8%. Retreatment was required in
7.8% of aneurysms.

Blood clot-related complications developed in 7.5% of procedures,
of which only 4.0% were symptomatic and 2.0% were permanent. Bleeding complications occurred in 3.0% of procedures. No patients experienced
aneurysm re-rupture after treatment.

"Patients who are not suitable for open aneurysm surgery or who have
recently had a life-threatening rupture and would be at high risk for additional bleeding if treated with conventional endovascular techniques
due to the need for blood thinners, now have a viable treatment option,"
says Dmytriw. "We hope that our results will help guide interventionalists
in the appropriate use of the WEB so that patients with challenging
brain aneurysms will have a safe option for care." Addition medical institutions continue to join the consortium, which plans to conduct
additional studies to assess the use of the WEB for diverse types of
aneurysms and to examine potential challenges to its use.

special promotion Explore the latest scientific research on sleep and
dreams in this free online course from New Scientist -- Sign_up_now_>>> academy.newscientist.com/courses/science-of-sleep-and-dreams ========================================================================== Story Source: Materials provided by Massachusetts_General_Hospital. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Adam A. Dmytriw, Jose Danilo Bengzon Diestro, Mahmoud Dibas,
Kevin Phan,
Ahmad Sweid, Hugo H. Cuellar-Saenz, Sovann V. Lay, Adrien Guenego,
Leonardo Renieri, Ali Al Balushi, Sri Hari Sundararajan, Joseph
Carnevale, Guillaume Saliou, Markus Mo"hlenbruch, Justin E. Vranic,
James D. Rabinov, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani,
Vedran Župančić, Muhammad U. Hafeez, Caleb Rutledge,
Muhammad Waqas, Vincent M. Tutino, Rawad Abbas, Yasuaki Inoue,
Carolina Capirossi, Yifan Ren, Clemens M. Schirmer, Mariangela
Piano, Anna Luisa Ku"hn, Caterina Michelozzi, Ste'phanie Elens,
Robert W. Regenhardt, Sherief Ghozy, Naif M. Alotaibi, Stavropoula
Tjoumakaris, Robert M. Starke, Boris Lubicz, Pietro Panni, Ajit
S. Puri, Guglielmo Pero, Christoph J.

Griessenauer, Hamed Asadi, Mark Brooks, Julian Maingard, Ashu
Jhamb, Adnan Siddiqui, Andrew F. Ducruet, Felipe C. Albuquerque,
Peter Kan, Vladimir Kalousek, Pedro Lylyk, Amey Savardekar,
Srikanth Boddu, Jared Knopman, Nicola Limbucci, Karen S. Chen,
Mohammad A. Aziz-Sultan, Christopher J. Stapleton, Pascal Jabbour,
Christophe Cognard, Aman B.

Patel, Nimer Adeeb. International Study of Intracranial Aneurysm
Treatment Using Woven EndoBridge: Results of the WorldWideWEB
Consortium.

Stroke, 2021; DOI: 10.1161/STROKEAHA.121.037609 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/01/220106143648.htm

--- up 4 weeks, 5 days, 7 hours, 13 minutes
* Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)