we treated 20-month-old non-transplanted, wild-type mice with D+Q or V intermittently for 4 months



For all dasatinib+quercetin (D+Q) treatments, D (5mg/kg, drug/body weight) and Q (50mg/kg) were administrated by oral gavage in 100-150 μL 10% PEG400. For treating 20-month-old mice, D+Q was delivered either once monthly or every 2 weeks, with
essentially identical effects. For the lifespan study, 24-27-month-old mice were treated with D+Q or V for 3 consecutive days every 2 weeks.



Note: it might just be a number on a screen, but on alibaba dasatinib is listed as $225 - $270/Kg, if that is so, and if 700mg as a mouse-compensated is a 4 month human dose, then a treatment which causes mammals, possibly humans, to live 20% longer is
less than 25 cents. Notably if this made with liposomes then it might be 4 times as bioavailable, making a 20% increased longevity drug at 7-8 cents for a full treatment. That could benefit humans globally.



Dasatinib: 350 mg every 24 hours, three consecutive days every two weeks for 4 months is 8.4 grams dasatinib from alibaba. Note this ignores the mouse compensation number, with mouse compensation number this is 700mg for a treatment, or about 29.167
milligrams a day



Quercetin is 3.5g every 24 hours, 84 grams for 4 month treatement without mouse compensation factor. With mouse compensation factor it is 292 mg/24 hours, 8.4 grams for 4 month treatment.



Rapamycin 60% longevity increase at lab mammals:

“3 months of rapamycin treatment is sufficient to increase life expectancy by up to 60% and improve measures of healthspan in middle-aged mice.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996648/

“receiving rapamycin injections relative to vehicle treated controls (Figure 1A), although food intake remained similar during the treatment (Figure 1—figure supplement 2). Decreased body weight persisted for several weeks following cessation of
treatment (Figure 1A). This was accompanied by a striking increase in median life expectancy from the end of treatment of 60%”

However, rapamycin might work on mice from preventing or delaying cancer, “supporting the notion that rapamycin extended lifespan by specifically inhibiting neoplasia-related lethality” However, a sa youthifier rapamycin causes mice of the same age
to be more cognitively able and physically lively than untreated mice, “Rapamycin treatment, however, improved learning and memory in the Morris water maze not only in animals that were aged on the drug, but also in young adult mice (treatment starting
at 6 months and lasting for 6 weeks)”



Rapamycin dose: “(8mg/kg/day)” at 53% lifespan increase.



compare injection and liposomes to plasma half life and absorption; liposomal vitamin c is 93% biolavailable compared with 19% oral; so oral dose might be 4 times higher than injection dose:



560 mg/24 hours before mouse compansation factor and .25 times multiplier for oral compared with injection. (look up oral compared with injected human rapamycin plasma levels) is 187 mg/24 hours with mouse compensation number and four times the dosage
because of oral.



Oral rapamycin at food, 3 months at 126 ppm ad libitum feeding, “to assess whether transient treatment with a lower dose and different delivery of rapamycin might reduce side effects in female mice and increase lifespan in both sexes, we utilized
dietary eRapa at 126 ppm. Mice were fed a diet containing eRapa or the encapsulation control eudragit diet for 90 days starting at 20–21 months of age and then returned to a standard chow diet. In contrast with the effects of daily injection of 8 mg/kg
rapamycin (Figures 1A and and2A),2A), body weight and food intake were largely unaffected by this dietary rapamycin regimen (Figure 4 A,C,E, Figure 4—figure supplement 1), except for a transient, small increase in body weight in female mice fed eRapa,
as determined by Student’s t test (Figure 4E). Median post-treatment life expectancy was significantly increased by 42%”



126 ppm; 1000 ppm is like 1 gram per Kg food so that is like 126 mg/Kg of mouse food. A mouse eats 2 or 3 grams of food a day, so 126 ppm at 3 grams is (amount) and a mouse weighs 25 grams, so a 70 kg human has a mass of 2800 mice, or a dose of 3 grams
times 126 ppm * 2800, 8400 grams of food a day, or 1.06 grams of rapamycin human dose, without mouse compensation number, with mouse compensation number that is 88.2 mg/24 rapamycin hours at a human as oral rapamycin with food, perhaps eaten throughout
several times a day.



rapamycin is sometimes encapsulated with: “enteric coating material Eudragit” s100, they are described as variations on methacrylate polymers, “EUDRAGIT® S polymers are highly stable and can be easily combined with other polymers or oral drug
delivery technologies for precise targeting and rapid dissolution within either the small intestine or colon.” eudragit S versions dissolve around 100-150mg/minute or higher at basic high pH around 8-8.5 https://healthcare.evonik.com/sites/lists/NC/
DocumentsHC/Evonik-Eudragit_brochure.pdf

Possibly enteric capsules of some known formulation that reach small intestine or otherwaise say they are a high pH dissolving pill, could be used at a 3-4 month dose course as well as a different dose course with liposomal rapamycin.





So, 90 days mouse uncompensated entire consumed amount is 95.4 grams, with mouse compensation number 7.95 grams for a full 90 day human treatment. At 14 ppm compared with 126 ppm, the 14 ppm dose is 10.6 grams uncompensated, 883.34 mg compensated.



Food or IP injection graphs suggest about double effectiveness with 128 ppm of encapsulated rapamycin in food compared with injection.



Rapamycin at food was encapsulated, “For the feeding model, encapsulated rapamycin was obtained”



although the rapamycin in the food was microencapsulated, It could possibly be of value for the human to imitate the lipid/carbohydrate/protein blend and digestability if the mouse food at the human food, noting varied absorption with fatty or
carbohydrate rich human foods (3 times different deprenyl). Liposomes could be highly beneficial related to, “rapamycin-sensitive cancer models, but its poor water solubility greatly hampers the application”





Note: numerous published studies show longevity increase at 14 ppm at food, the 60% greater longevity study uses 126 ppm at food, or 8 mg/Kg IP injection. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207939/



Rapamycin causes greater cognitive ability at mice, it is possible that if this is perceptible to a human, then using the mouse dose as a guide, amounts of rapamycin above the mouse dose could be guided by any human measureable or perceptible increases
in congitive ability. Perhaps if a person tries 1.5 times as much rapamycin one day, then the person notices cognitive effects that same day, and the upper dose would be the congition optimizing dose, possibly above the mouse longevity dose.





$50/gram rapamycin on alibaba (or more affordable) is



Epithalon longevity peptide is on alibaba at $2.50 -$5.50/ each 10 mg dose or $100/gram Thymosin is on alibaba at $3.50-$9.00 a 5 mg dose, single doses available. epithalon is described as decreasing mortality at rats or possibly drosophila 52%, and
makes ill mice live 27% longer. https://www.peptidesciences.com/epithalon



The combination of epithalon with thymosin is published as making people four times less likely to be dead after 6 years. Liposomal version, perhaps with enteric basic pH capsules, could be utilized at one dose group, and nasal administration at another
seperate dose.



Thymosin is an immunostimulant and has some research about utilization with immunizations to make the immunizations stronger, thus the CuSO4 with protein or other material amateur vaccines could benefit from coadministration with thymosin notably at the
CuSO4 with other material immunizations; thymosin effects dendritic cytes which are the cytes that first reach and pattern around an antigen; dendritic cytes are particularly numerous at nose, skin, “GI system”, GI system suggests enteric capsule or
liposome version of CuSO4 antigen could be effective, producing an oral vaccine rather than a make a CuSO4 rash or skin reaction vaccine.



CuSO4 cholesterol, or CuSO4 testosterone as oral vaccine pills could reduce cardiovascular disease and be longevizing, particularly if immunizing against testosterone causes enunch level longevity increase of 14-19%. It is possible that mushed up or
enzyme digested testicular tissue with CuSO4 as pills could immunize against a wide range of testicular chemicals and proteins, possibly causing the body to wipe out a variety of testicular products and tissues, notably this could have risk as some of
the numerous widely different proteins might be at other body structures. Perhaps solvent extraction of ground animal testicles could produce a lipid-soluble, filtered to be absent protein, fraction with a lot of steroids in it for the CUSO4 to be
combined with to make a longevity vaccine.

Do other metals that are antigenic like Ni, perhaps others, have value as co-adminstered amateur vaccine constituents, like NiSO4 testosterone coadministered with CUSO4 testosterone? “If you're allergic to nickel and you're sweating, you can start
feeling an itchy allergic reaction within 15 minutes of touching a nickel-containing product. However, if you're not sweating, you may not react for a few hours. After a day or two, you'll probably notice a rash.”



Noting I am already allergic to some animals, it is possible that animal dander concentrate mixed with testosterone could immunize against testosterone, causing enuch like longevity increase.

Note: TOR websites might have actual testosterone or DHT to make into a vaccine, with less physiological risk than CuSO4 with lipid fraction of ground up testicles. JY says there is an absence of government penalty to my actions beyond 45 days of
dentention, which has already occurred, thus there is likely an absence of risk.



CuSO4 with cholesterol is a published effective anticholesterol vaccine at lab mammals.

the toxic dose of Cu is compared with the immunogenic amount, “With an LD50 of 30 mg/kg in rats, "gram quantities" of copper sulfate are potentially lethal in humans.[21] The suggested safe level of copper in drinking water for humans varies depending
on the source, but tends to be pegged at 2.0 mg/l.”

One possibility is a 10-30mg snortable or nasal spray CuAntigen immunization administered, voluntarily, nasally.



It is possible a 1 or 7 day sequence of CuSO4 with antigen pills could be below that 2mg/L to 30 mg (note at 70 Kg the possible Cu amount could be more than 30 mg, but perhaps 7 days at 30 mg are much less harmful, and more antigenic than an 270mg single
dose.) Cu dose, It is possible 30 mg of CuSO4 with material to be immune responded to, at enteric capsules as an immunization ingredient are absent symptoms while being immunogenic.



Alibaba: $30/38/g dasatinib, $135 for 10 grams

$30 https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSFvkscRzFwZlpqQBdmXs



$10/g dasatinib, $46/10g https://message.alibaba.com/message/ma.htm?spm=a2700.9014153.0.0.62273e5fqTueh7#/



$10/g $48/10gdasatinib https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQcZCtkcvxvZRsfPldNCxB



100g quercetin $8.50

https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSFvkqNwJXjcXZMNRKdfj

1 kg $44 plus shipping https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSFtgnnSbmgqCPPLqVfdH



Royal Jelly $ 86.60, 95, 106-114/Kg

86.60, possibly: https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSJMGVlHnBLtTQQRwGbCQ

86.60 “4% HDA” also https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSJLLbCsWDKXZgnsMhMXq



Zero shipping cost, unknown HDA, likely 6%, ebay, $139.96 https://www.ebay.com/itm/BulkSupplements-Pure-Royal-Jelly-Extract-Powder/192780658370?var=492923737357&_trkparms=ispr%3D1&hash=item2ce29f66c2:m:mbBxbJBob9GpgOOPaiFJxmg&enc=AQAEAAAB4BPxNw%
2BVj6nta7CKEs3N0qXgCBKsHCJ8eg2Fn3XVtJsOp5msd0Y07fY71SooPDsEHX50xrV%2BTRyVWGAkh%2BN2ImKSqgv5OmCeQn2NkSqgYcAWC2FPp%2FylsTVW2N0MlmmfkhrbvNkhFU%2F%2B5p%2FO8fqpc1V1mbZgLiA7%2BLTr1%2FLo3UciJ3c%2F32ZnIfhzxlZDLMmYT56V1NxfN6CD5imxhrV%
2BaSIny89hYibC0A399POpWkkOrQxsJ2QOfXEXtGwBLanir0ocfQSEaVpBl%2FtpkQtiyq2%2BhdUAmT2jGrDU2%2BcSA6WA3Dh4W%
2FH1Kb7oK9VLPFi9vOykPoPEDpDVbvGKuGvVhGm2OcEUWPytmBg1nyxWp8qJ7le3TTaaGs43HFRnJIFnoKe9U1w77a1pEp45wo6xuKFJ6qtEUdBhnyEyxnhsVOQkP86G1TEuIaDrGr4odhwIKp2jvA62twSjcU4YF7IrOEtCGRpvM%2B%2FZsZ7%2FQdAm%2BhKmdKOYSbHNp8QNprwjLdKNQyTM3ntzOz8raZj%
2BK65tLSQS3Tqi2tMXIyXJhOKhwW599PtQKlliqBkkHgQVZUVmkguMA5Y7LsZfuav3x8T66K%2ByvYt7T%2F0UxmqHqBIyEiVT3TkctUiWkmVKIYvMSHUKXQ%3D%3D&checksum=192780658370d41de73f34014797bad5b99877780819



$95 https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSJLwSGhTCQVVsDnmtLbb



$106-114 (4) or (5)% HDA, so, perhaps 20% more longevity benefit from $8? https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSHDNvqMKbRHQVgVrptTh

$105 (6%) HDA https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQSHCmQFtKKbvKNNWgpxGd



Royal Jelly Powder with 10 HDA 3.0% usd 60/kg, $77.5 (4%) to 90 (5%) :Royal Jelly Powder with 10 HDA 4.0% usd 77.5/kg

Royal Jelly Powder with 10 HDA 5.0% usd 90/kg https://message.alibaba.com/message/ma.htm?spm=a2700.9014153.0.0.62273e5fqTueh7#/

3%HDA $67 https://message.alibaba.com/message/ma.htm?spm=a2700.9014153.0.0.62273e5fqTueh7#/

3% HDA $50 https://mail.google.com/mail/u/0/#inbox/FMfcgxwDqTdQchxDPXqSzJjLzzmTVHQW



This says that their product is white, and thus higher purity, 5%, $90/Kg $30 shipping, https://message.alibaba.com/message/ma.htm?spm=a2700.9014153.0.0.62273e5fqTueh7#/

Math: same amount of royalactin regardless of HDA amount, so eating 20% or double the amount of royal jelly to get an HDA amount, happens to cause a greater dose of royalactin per day, which also has published benefit, so it is possible 3 or even 4% HDA,
at double dose compared with 6% HDA, made affordable from half $ at different HDA, causes greater actual benefit from doubling royalactin and other royal jelly components; the 27% longer lived mice were getting whole royal jelly rather than just HDA, so
double dose at .5 cost could actually have more longevity benefit per $.

The 27% mouse lifespan increase dose of 126 mg/Kg combined with the HDA dose that causes 25% less blood glucose from modulating AMPK at 3 mg/Kg/24 hours HDA is 210 mg, with mouse compensation factor is 17.5mg, at 3% that is is 583.28 mg/24 hours, at 6%
it is 291.6 mg of royal jelly.

So combining these two, a 3% royal jelly dose is, and a 6% dose meets or going beyond the 27% human dose, mouse compensated, greater mouse longevity dose of 735 mg/ 24 hours, suggests that the HDA benefit (at 583 mg/24 hours), can be combined as effects
where 735 mg/24 hours provides more HDA than the published AMPK modulatation while being at the 27% longevity increase dose.

At various other published studies higher doses of royal Jelly or HDA were published as having benefit. To make 1 Kg supply 365 days, is 2.74 g/24 hours, with 82.2 mg of HDA/24 hours. That is 6.5 times the 2 times longevity dose, or 1.96 times the (10
times other dose interpreted as being a high dose) 27% greater longevity amount. The mammals were fed the royal jelly to attain 27% greater longevity so the royal jelly was processed by the stomach. It is unknown if enteric capsules could double the
amount of absorbed protein, or if liposomes could quadruple the amount of absorbed royal jelly chemicals. four or eight times the 27% longevity increase dose could come from enteric capsules or liposomes at 1Kg/365 day dose amount.

One benefit of 1Kg/365 days of liposomal royal jelly is that it stays fresh. Also, it goes up from 27.3 cents/24 hours to some other number as the liposomal ingredients or enteric capsules make it be more cents, but it is unlikely that the liposomal
ingredients or enteric capsules, ignoring the outlay are more than 10 cents/24 hours, so near 37.3 cents/24 hours to dose with a 4 to 8 times higher amount for longevity; notably some royal jelly and HDA studies use even higher doses of royal jelly and
HDA, so the 4 or 8 times multiplier could be physiologically beneficial.

Although the 27% lifespan increase laboratory mammals ate, and directly digested the fresh royal jelly, it is possible eneteric capsules double, or liposomes quadruple the absorption of royal jelly chemicals. Of course, what if these proteins and lipids
are beneficially modified by digestion to become active? That suggests a 1/2 eaten as is, 1/2 enteric or liposomal method of dosing. Noting the 1/2 eaten as is is provides 1.37g, an amount greater than the amount of milligrams to provide the amount of
DHA and royal jelly that provides the 27% greater longevity and beneficial AMPK modulation.

One other dose amount benefitting effect: one kilogram of lyphilized royal jelly has an equivalent amount of fresh royal jelly. If the dried to fresh volume ratio is 2, then the 1Kg/365 2.74 g/24 hours doubles to be 5.48 grams of fresh royal jelly mass
every 24 hours. If the fresh mass to lyophilized mass ratio is 1.5:1 then it is like 4.11 grams of royal jelly every 24 hours.



rapamycin

This might be $100/gram, including shipping; 700 mg, with mouse compensation factor, is a 4 month course $199 for 2 grams rapamycin https://message.alibaba.com/message/ma.htm?spm=a2700.7756200.0.0.7bd81afaohuJTe&from=rfqlist&showUnread=true#/



Longevity technology:

Gene therapy as well as germline modification that decreases mTOR activity, much like the drug rapamycin decreases mTOR activity, is a way to increase longevity at humans. Making an mTOR longevity, wellness, cognition maintaining or magnitude increasing,
happiness increasing or maintaining genetic variation is a gene therapy that is likely to cause greater longevity even though the gene therapy is likely to have higher and differing transfection at different tissues; beneficial to humans is creating or
finding an mTOR gene that has less mTOR activity which then increases longevity, wellness, while maintaining or increasing cognitive ability, as well as increasing happiness or maintaining it. It is possible that immunodecreasing effects of reducing
mTOR activity could be compensated completely or even to the immune system benefit to the organism, if the gene therapy or germline modification increases or also codes to produce a larger amount of the thymosin peptide at the body, strengthening the
immune system even while decreasing mTOR activity that modulates the immune system while it increases longevity and wellness, as well as has published effects on cognitive function maintenance or cognitive capability increase, as well as contributing
greater human happiness from the positive psychology increase that goes with each human’s longer duration, and higher amplitude feeling of having wellness and being well.



Interestingly, studies of positive psychology have measured that the subjective idea of how healthy people believe they are contributes measurably to their subjective well being, so germline gene modification or also gene therapy that causes greater
longevity and duration of wellness from decreasing mTOR activity can cause greater sustained wellness. The longevity component also gives humans more and more years to be happy in. Noting the rapamycin 60% lifespan extension at rodents, optimized mTOR
genes could have the same effect on humans, giving many more decades of living to be happy in, while also making people feel subjectively healthier, because they happen to be objectively physiologically weller at any particular age. This is why mTOR
expression decreasing gene modification is also a happiness increasing gene modification. Wikipedia says, “Genetic reduction of mTOR expression in mice significantly increases lifespan.”



If you just immunize against the mechanistic target or rapamycin receptor protein, does it work less, be stimulated less, or become blocked with antibodies such that it functions like an mTOR inhibiting drug like rapamycin or and mTOR activity decreasing
gene therapy or germline gene modification; if so, then immunizing against mTOR receptor proteins is a longevity drug that could function from one injection, or optimally, one oral dose.



A bacteria that makes lipopolysaccharides attached to mTOR receptor proteins might be a bacteria endemic to humans as well as other mammals that causes greater longevity in all the species it colonizes, one possibility is a probiotic, another possibility
is a skin surface bacteria, or a bacteria that saturates the environment even if it does not actually live on any particular mammal, thus just breathing, drinking water, or resting bare skin or a nose on grass could expose the mammal to the mTOR activity
decreasing immunogenic against mTOR proteins, this causes greater mammal longevity and wellness at a a variety oif species and could even increase the longevity of nonmammals.



Fishing nets, with a particular ratio of fish gathering to pass-through that also immunizes against mTOR proteins, which decreases mTOR activity, and increases fish lifespan on contact with its immunogenic filaments could cause fish populations that are
fished with these nets to cause fish that live longer to reproduce more times, and cause fish too small to be netted to be more likely to live to larger sizes; this creates a fishing net that actually increases the number of fish; note I am a vegetarian
and think people should cease eating fish, it just seems nifty that it could be possible to make a fishing net that harvests fish while actually increasing the number of fish in the environment. Also these are actual fish species rather than metaphorical
fish.



Appreciating Dave Pearce and his teaching me to improve well being at all sentiences; an environmental bacteria that makes all animals live longer supports Dave Pearce’ preferences and plans for a more benevolent and what I describe as simultaneously
utilitarian everything.



An amateur immunization might be able to combine mass fraction sorting and possibly some kind of immunosorption to concentrate mTOR receptor proteins from lysed cytes, then combine them with an immunsensitizer, two possibilities being CuSO4 and NiSO4, to
create a longevity immunization. This could be tested on laboratory animals as well as being a globally available make-anywhere longevity drug.



Longevity plant that causes 60% or greater longevity increase: Plants contain something very much like the mTOR proteins, “the Arabidopsis thaliana TOR was named AtTOR”; A plant based immunogen combined with plant AtTOR protein, or a modified AtTOR
protein that has more peptides or protein moeities that make it into an immunogenic mTOR antigen, causes a plant or also plant product to be a one exposure longevity and wellness drug that could last a human’s entire life causing greater longevity and
wellness; One dose, only once, but with multiple doses being harmless is better, it could also be immunologically renewed from drinking or eating some plant juice or part of a plant.

Another possibility is just making an AtTOR protein receptor expressing plant tissue or juice protein concentrate and snorting it with CuSO4 or spreading it on the surface of abraded skin to elicit an antibody response to the near-mTOR AtTOR proteins,
immunoresponse to mTOR receptor proteins then reduces the person’s own mTOR activateability, which then increases lifespan and wellness at the person; genetically engineering a plant to make very large amounts of AtTOR receptor proteins (to
immunosensitize organisms to their own mTOR receptors, causing those mTOR receptors to be less active) and immunosensitizing antigens simultaneously or as parts of one continuous protein at it’s delicious leaves or fruit creates a autopropagating from
its deliciousness new longevity wellness plant; with optimization it could produce the 2016 60% greater mammal longevity from rapamycin dosing effect or larger effects (one possibility to make mTOR activity decrease cause even greater longevity than that
published at the 2016 AD rapamycin studies is to find those tissues that are least exposed to ingested rapamycin, then make new drugs that localize at those previously minimally exposed tissues to effect mTOR receptors at those previously less-drugged
tissues; it is possible an mTOR receptor immune response could actually be at more tissues, and with greater absolute mTOR response decrease than caused with medication with rapamycin, this causes the immunogenic mTOR activity reducer to cause even
greater longevity and wellness effects) . Humans benefit from a plant, which if eaten even just once, makes them live 60% longer, or even greater spans. As a plant, this benefits people globally, independent of their culture, its patterns and resources.



Immunizing against things that cause mTOR activity could decrease background or baseline mTOR activity and the immunization would cause greater longevity from reducing mTOR activity





apre and pre TOR .8 each 1.6 as effective as mtor activity reducer together.



skinny virus with halogenated PEA has virus particles that make longevity drugs like mTOR reducers possibly from antibodies to mTOR receptors



Women like it, its a great way to have fun making money as mental and written content at beneficial things, possibly causing mental overlap persons to seize the moment and act, but is that ethical?



meiosis and stem cell versions of mTOR activity redcution, si RNA or other things that cause the actual amount of mTOR receptors at the new cells from meisos to have actual less quantiuty, possibly something that effects the endoplasmic reticulum? have
plants, probiotics, snortable beneficial viruses, gene therapy or even germline modification produce the siRNA tht causes the endoplasmic reticulum to populate new meiosis generated cytes to have fewer mTOR receptors and thus be part of an organism wide
trend, and possibly tissue specific improvements at having 60-72% greater longevity.

Stem cell based reduction of mTOR receptors, along with the comparatively fewer than meiosis generated cells at a grown organism amount of stem cell generated cytes are the possible huge amounts and trends of cell form from blastocyst and zygote
differentiation and growth; it is possible that a fetus could be said to grow from stem cells, in the sense that the blastocysts is undifferentiated and the zygote is differentiated and generating many new cell types and tissue with continuing increases
in cell differentiation throughout zygote and fetal development; siRNA that very beneficially effect a conceptus to make the phenotype of that conceptus, fetus, baby and person live 60-72% longer and, like the mice with mTOR activitity greater expressed
spontaneous activity and greater cognitive frunction, from the siRNA causing the stem cells and other undifferentiated cells have



mTOR, do things like rapamycin like, halt changing the “volume knob” at all, or change the threshold so that only really loud mTOR shifters cause change, or do they just occupy 9/10th of the receptors reducing mTOR activty 9/10ths? Each of these
could be a separate kind of drug action, each with its own kind of drug, organismal sourced effect (beneficial viruses, probiotics, gene therapy), or germline gene modification.



rapamycin published as causing 60% greater mouse longevity from 90 treatment in mice, it is a perception that engineering can often do much better than making something 20% more effective, so 60% improved 20% is 72% greater longevity; one possible source
of the 20% engineering increase in rapamycin/rapalog/other mTOR treatment effectiveness is pre and apres MTOR cytochemical connection diagram item increase or decrease with completely different drugs or therapies. I perceive that previously described is
making a large molecule number library of rapamycin molecule variants, screening their longevity effects on yeast, then finding out their effects on mice. One possibility is what was described as a microfluidic binomat that makes hundreds of millions or
billions of molecule variants and the apparatus to test them. Other simple things like halogenation, ethynylization, liophilicity and hydrophilicity adjustments, and linking rapamycin to peptides or proteins that cause membrane transport, or even just
transport to the intracellular between cell spaces.



Is mTOR’s longevity effect an exterior cytomembrane receptor based effect? If it is is there a cytoplasmic functionalike that could be addressed with peptides or proteins? a cytoplasm side mTOR activity reducer could be a new kind of longevity drug,
beneficial physiologically resident organism product, gene therapy, plant sourced effect, or drug.



Think of a cow whose milk makes people live 7 decades longer from just a few sips from a glass, the cow’s milk contains antigens that cause an immune response to the mTOR receptors at the cells.



“in sum, oral rapamycin has stimulatory effects on locomotor behavior [11, 13, 18, 19] and improves learning and memory [13, 20, 21]. These are robust findings seen across mouse strains and genders. Because rapamycin has similar effects in young
animals and aging cohorts [13], it is the most parsimonious explanation of the data that these rapamycin effects are not related to a modulation of aging.” One paper says mTOR has both cognitive decreasing and increasing effects. Rapamycin causes mice
that have taken it from 2 months to 18 months of age to be about 25% better at a learning activity, although giving it to 15 month old + did not rescue them from cognitive nonoptimality compared with young mice; mTOR activity also supports, “inhibiting
mTOR with rapamycin has detrimental effects on long-term memory facilitation and consolidation in gerbils”. mTOR activation both detracts from and supports cognition. mTOR longevity increasing drugs that effect things upstream or downstream from mTOR
might be developable that are completely cognitively beneficial, or perhaps coadministration of an mTOR drug with a long term memory facilitating drug could produce a net beneficial cognitive effect.



a pre mTOR affecting protein is “mTOR-related cell signaling. AKT serine/threonine protein kinase, AMPK AMP-activated protein kinase, FKBP12 12 kDa FK506-binding protein” The genetics of FKBP12 could be longevity genetics, as well as cognitive and
spontaneous energetic movement genetics; modified proteins that have an effect on longeveity could be made from FKBP12, along with FKBP12 similars that block activation, or effect activation differently could be versions that outnumber endogenous FKBP12
hundreds of times. modified versions of this protein could function only at those cytosytems that promote longevity and omit other enzmatic effects.



Making senolytics and their longevizing effects more popular could be that dasatinib with quercetin causes greater nitric oxide response functionality, which is associated with sexual function. Greater penile firmness or erection initiation could occur
durably after a course of senolytics that also increases longevity. This could also benefit clitoris function and vaginal blood engorgement.




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