On 06 Feb 2025 13:55:46 GMT, Retrograde <
fungus@amongus.com.invalid>
wrote:
Link: https://www.sciencedaily.com/releases/2025/02/250205131617.htm
A research team has developed a biodegradable polymer-based delivery system >that efficiently transports mRNA.
Since the COVID-19 pandemic, global interest in mRNA vaccines has
surged. Among existing delivery methods, lipid nanoparticles (LNPs)
are widely used due to their high efficiency. However, LNPs have a
critical drawback: once injected, they can accumulate in the liver,
potentially causing toxicity or triggering an excessive immune
response, which in severe cases may lead to anaphylaxis.
To address this issue, the POSTECH research team explored the
biodegradable polymer Poly B-amino ester (PBAE) as an alternative.
....
Experimental results demonstrated that the newly developed polymer
exhibited higher mRNA delivery efficiency compared to conventional
LNPs. Additionally, mRNA expression lasted up to four weeks --
significantly longer than the typical five-day expression period of
LNPs. Notably, the polymer ensured mRNA expression only at the
injection site, with no detectable expression in the liver, thereby
eliminating toxicity concerns.
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